Vinyl Chloride And Hcc

Vinyl chloride vc is a know animal and human carcinogen associated with liver angiosarcomas las and hepatocellular carcinomas hcc.

Vinyl chloride and hcc.

However no data about the prevalence of such mutations in vc associated hccs are available recent data indicate k ras 2 mutations induce p16 methylation accompanied by inactivation of. In 2007 the international agency for research on cancer established the association of vcm with hepatocellular carcinoma hcc though o. Objective to evaluate mortality risks of angiosarcoma of the liver asl primary hepatocellular carcinoma hcc and other cancers among 9951 men employed between 1942 and 1972 at 35 us vinyl chloride vc or polyvinyl chloride plants followed for mortality through 31 december 2013. The results from the two large multicenter studies and the pooled meta analysis are presented in table 2.

The most up to date and most comprehensive analy ses is a pooled analyses of cohorts of vcm workers from. In fact the assessment of vinyl chloride as a cause of hcc is complicated because most studies do not have histological or other definitive clinical information to discriminate hcc from asl and or secondary neoplasms. Vinyl chloride is a chlorinated hydrocarbon occurring as a colorless highly flammable gas with a mild sweet odor that may emit toxic fumes of carbon dioxide carbon monoxide hydrogen chloride and phosgene when heated to decomposition. 2 after the first report of three cases of asl in subjects employed in the manufacture of pvc resins 15 epidemiological.

In vc associated las mutations of the k ras 2 gene have been reported. Recently the international agency for research on cancer has also included vc among the definite causes of hcc 1 but this assumption is not. About 13 billion kilograms are produced annually. Portal hypertension liver fibrosis and angiosarcoma of the liver asl have been reported among workers exposed to vinyl chloride monomer vcm since the 1970s.

Portal hypertension liver fibrosis and angiosarcoma of the liver asl have been reported among workers exposed to vinyl chloride monomer vcm since the 1970s. Plants in the usa and europe 41. Vinyl chloride and hcc. Vinyl chloride is an organochloride with the formula h 2 c chcl that is also called vinyl chloride monomer vcm or chloroethene this colorless compound is an important industrial chemical chiefly used to produce the polymer polyvinyl chloride pvc.

Vinyl chloride and hcc the most up to date and most comprehensive analyses is a pooled analyses of cohorts of vcm workers from plants in the usa and europe 41. Methods smr and time dependent cox proportional hazards analyses were used to evaluate mortality risks by. The results from the.