Chronic exposure leads to common forms of respiratory failure emphysema pulmonary fibrosis and focused hepatotoxicity hepatomegaly hepatic fibrosis. These causative agents normally belong to the class of carcinogens. Angiosarcoma may also arise as a complication of radiation therapy long standing lymphedema exposure to chemicals e g hepatic angiosarcoma after exposure to vinyl chloride and rarely as a secondary component of other tumors e g germ cell tumors.
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