Vinyl Chloride Exposure Hepatic

Meta analysis of studies of occupational exposure to vinyl chloride in relation to cancer mortality.

Vinyl chloride exposure hepatic.

Workplace exposure to vinyl chloride is also known to cause cancers and other types of liver disease. The main sources of information for this fact sheet are the agency for toxic substances and disease. It was not possible to apply a best evidence approach to the study of liver cancer and consequently it is not possible to distinguish between hepatic angiosarcoma and hepatocellular carcinoma. It also has other toxic effects on the liver and it has recently been suggested that exposure to vinyl chloride also causes hepatocellular carcinoma.

Iarc monographs on the evaluation of carcinogenic risks to humans vol 97. However the data on which this conclusion is based is incomplete. The target organs for vc now clearly in. Additional research has now demonstrated the carcinogenicity of vc to other organs and at lower concentrations.

Vinyl chloride exposure is associated with an increased risk of a rare form of liver cancer hepatic angiosarcoma as well as brain and lung cancers. Which cancers are associated with exposure to vinyl chloride. Exposure to vinyl chloride occurs mainly in the workplace. Portal hypertension liver fibrosis and angiosarcoma of the liver asl have been reported among workers exposed to vinyl chloride monomer vcm since the 1970s.

Breathing vinyl chloride for long periods of time can result in permanent liver damage immune reactions nerve damage and liver cancer. In 1949 a russian publication discussed the finding that vinyl chloride caused liver injury among workers. In the very first study about the dangers of vinyl chloride published by patty in 1930 it was disclosed that exposure of test animals to just a single short term high dose of vinyl chloride caused liver damage. Epa has classified vinyl chloride as a group a human carcinogen.

Breathing high levels of vinyl chloride for short periods of time can cause dizziness sleepiness unconsciousness and at extremely high levels can cause death. Bofetta p matisane l mundt ka dell ld. 1 3 butadiene ethylene oxide and vinyl halides vinyl fluoride vinyl chloride and vinyl bromide. The evidence of a causal link between vinyl chloride exposure and liver cancer is anyhow confirmed.

In 1974 vinyl chloride vc was first reported in the open scientific literature to induce angiosarcoma of the liver both in humans and in animals. Equally disturbing is the fact that pvc manufacturing plants are disproportionately located in low income neighborhoods and communities of color making exposure to this toxic chemical not only an issue of health and the environment but also. There is inadequate ascertainment of unequivocal diagnoses. If a water supply is contaminated vinyl chloride can enter household air when the water is used for showering cooking or laundry.